Making genomic medicine evidence-based and patient-centered: a structured review and landscape analysis of comparative effectiveness research.

ABSTRACT: Comparative effectiveness research (CER) in genomic medicine (GM) measures the clinical utility of using genomic information to guide clinical care in comparison to appropriate alternatives. We summarized findings of high-quality systematic reviews that compared the analytic and clinical validity and clinical utility of GM tests. We focused on clinical utility findings to summarize CER-derived evidence about GM and identify evidence gaps and future research needs. We abstracted key elements of study design, GM interventions, results, and study quality ratings from 21 systematic reviews published in 2010 through 2015. More than half (N = 13) of the reviews were of cancer-related tests. All reviews identified potentially important clinical applications of the GM interventions, but most had s

SUBMITTER: Phillips KA 

PROVIDER: S-EPMC5629101 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature