Incorporating Gene Annotation into Genomic Prediction of Complex Phenotypes.

ABSTRACT: Today, genomic prediction (GP) is an established technology in plant and animal breeding programs. Current standard methods are purely based on statistical considerations but do not make use of the abundant biological knowledge, which is easily available from public databases. Major questions that have to be answered before biological prior information can be used routinely in GP approaches are which types of information can be used, and at which points they can be incorporated into prediction methods. In this study, we propose a novel strategy to incorporate gene annotation into GP of complex phenotypes by defining haploblocks according to gene positions. Haplotype effects are then modeled as categorical or as numerical allele dosage variables. The underlying concept of this approach is t

SUBMITTER: Gao N 

PROVIDER: S-EPMC5629318 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature