Selection Constrains High Rates of Tandem Repetitive DNA Mutation in Daphnia pulex.

ABSTRACT: A long-standing evolutionary puzzle is that all eukaryotic genomes contain large amounts of tandemly-repeated DNA whose sequence motifs and abundance vary greatly among even closely related species. To elucidate the evolutionary forces governing tandem repeat dynamics, quantification of the rates and patterns of mutations in repeat copy number and tests of its selective neutrality are necessary. Here, we used whole-genome sequences of 28 mutation accumulation (MA) lines of Daphnia pulex, in addition to six isolates from a non-MA population originating from the same progenitor, to both estimate mutation rates of abundances of repeat sequences and evaluate the selective regime acting upon them. We found that mutation rates of individual repeats were both high and highly variable, rang

SUBMITTER: Flynn JM 

PROVIDER: S-EPMC5629333 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature