A Mixed Model Approach to Genome-Wide Association Studies for Selection Signatures, with Application to Mice Bred for Voluntary Exercise Behavior.

ABSTRACT: Selection experiments and experimental evolution provide unique opportunities to study the genetics of adaptation because the target and intensity of selection are known relatively precisely. In contrast to natural selection, where populations are never strictly "replicated," experimental evolution routinely includes replicate lines so that selection signatures-genomic regions showing excessive differentiation between treatments-can be separated from possible founder effects, genetic drift, and multiple adaptive solutions. We developed a mouse model with four lines within a high running (HR) selection treatment and four nonselected controls (C). At generation 61, we sampled 10 mice of each line and used the Mega Mouse Universal Genotyping Array to obtain single nucleotide polymorphism (SNP

SUBMITTER: Xu S 

PROVIDER: S-EPMC5629339 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature