APOBEC signature mutation generates an oncogenic enhancer that drives LMO1 expression in T-ALL.

ABSTRACT: Oncogenic driver mutations are those that provide a proliferative or survival advantage to neoplastic cells, resulting in clonal selection. Although most cancer-causing mutations have been detected in the protein-coding regions of the cancer genome; driver mutations have recently also been discovered within noncoding genomic sequences. Thus, a current challenge is to gain precise understanding of how these unique genomic elements function in cancer pathogenesis, while clarifying mechanisms of gene regulation and identifying new targets for therapeutic intervention. Here we report a C-to-T single nucleotide transition that occurs as a somatic mutation in noncoding sequences 4 kb upstream of the transcriptional start site of the LMO1 oncogene in primary samples from patients with T-cell acut

SUBMITTER: Li Z 

PROVIDER: S-EPMC5629363 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature