Genome-wide identification of key modulators of gene-gene interaction networks in breast cancer.

ABSTRACT:

Background

With the advances in high-throughput gene profiling technologies, a large volume of gene interaction maps has been constructed. A higher-level layer of gene-gene interaction, namely modulate gene interaction, is composed of gene pairs of which interaction strengths are modulated by (i.e., dependent on) the expression level of a key modulator gene. Systematic investigations into the modulation by estrogen receptor (ER), the best-known modulator gene, have revealed the functional and prognostic significance in breast cancer. However, a genome-wide identification of key modulator genes that may further unveil the landscape of modulated gene interaction is still lacking.

Results

We proposed a systematic workflow to screen for key modulators based on genome-wide gene e

SUBMITTER: Chiu YC 

PROVIDER: S-EPMC5629553 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature