New statistical methods for estimation of recombination fractions in F₂ population.

ABSTRACT:

Background

Dominant markers in an F₂ population or a hybrid population have much less linkage information in repulsion phase than in coupling phase. Linkage analysis produces two separate complementary marker linkage maps that have little use in disease association analysis and breeding. There is a need to develop efficient statistical methods and computational algorithms to construct or merge a complete linkage dominant marker maps. The key for doing so is to efficiently estimate recombination fractions between dominant markers in repulsion phases.

Result

We proposed an expectation least square (ELS) algorithm and binomial analysis of three-point gametes (BAT) for estimating gamete frequencies from F₂ dominant and codominant marker data, respectively.

SUBMITTER: Tan YD 

PROVIDER: S-EPMC5629630 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature