SSRI antidepressant use potentiates weight gain in the context of unhealthy lifestyles: results from a 4-year Australian follow-up study.

ABSTRACT:

Objective

To examine the association between antidepressant use and weight gain, as well as the interaction with lifestyle factors.

Design

Longitudinal study.

Setting and participants

We used data from 2334 adults from two stages (4.4 years apart) of the North West Adelaide Health Study, including validated diet and lifestyle questionnaires, measured body weight and linked pharmaceutical prescription data.

Main outcome measures

Body weight change.

Results

188 (8.1%) participants had a mean annual number of 1-2 antidepressant prescriptions, and 212 (9.1%) had over two prescriptions. The mean annual weight gain was 0.12, 0.18 and 0.28 kg in non-users, low (1-2 prescriptions/year) and high (>2 prescriptions/year) antidepressant users, respectively. In multi

SUBMITTER: Shi Z 

PROVIDER: S-EPMC5629701 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature