Comparative efficacy and acceptability of antidepressant treatment in poststroke depression: a multiple-treatments meta-analysis.

ABSTRACT:

Objective

The aim of this study is to create a rank order of the comparative efficacy and acceptability (risk of all-cause discontinuation) of antidepressant treatment in poststroke depression (PSD) by integrating direct and indirect evidence.

Design

Multiple-treatments meta-analysis of randomised controlled trials.

Participants

Patients with depression following stroke.

Interventions

10 antidepressants and placebo in the acute treatment of PSD.

Outcome measures

The primary outcomes were the overall efficacy, defined as the mean change of the total depression score. The secondary outcome was the acceptability, defined as risk of all-cause discontinuation. These estimates as standardised mean differences or ORs with 95% CIs.

Results

We identified 1

SUBMITTER: Sun Y 

PROVIDER: S-EPMC5629745 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature