Distribution of PLGA-modified nanoparticles in 3D cell culture models of hypo-vascularized tumor tissue.

ABSTRACT:

Background

Advanced stage cancer treatments are often invasive and painful-typically comprised of surgery, chemotherapy, and/or radiation treatment. Low transport efficiency during systemic chemotherapy may require high chemotherapeutic doses to effectively target cancerous tissue, resulting in systemic toxicity. Nanotherapeutic platforms have been proposed as an alternative to more safely and effectively deliver therapeutic agents directly to tumor sites. However, cellular internalization and tumor penetration are often diametrically opposed, with limited access to tumor regions distal from vasculature, due to irregular tissue morphologies. To address these transport challenges, nanoparticles (NPs) are often surface-modified with ligands to enhance transport and longevity after lo

SUBMITTER: Sims LB 

PROVIDER: S-EPMC5629750 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature