Association between single nucleotide polymorphism rs9534275 and the risk of coronary artery disease and ischemic stroke.

ABSTRACT:

Background

The present study was to detect the association of single nucleotide polymorphism (SNP) in the breast susceptibility gene 2 (BRCA2) and the risk of coronary artery disease (CAD) and ischemic stroke (IS).

Methods

Genotypes of the BRCA2 rs9534275 in 1822 unrelated subjects (CAD, 606; IS, 569; and healthy controls, 647) were determined by the polymerase chain reaction and restriction fragment length polymorphism and then confirmed by direct sequencing.

Results

The genotypic and allelic frequencies of rs9534275 were significantly different between the CAD, IS patients and controls (P = 0.033 and P = 0.027; respectively). The GG, GT/GG genotypes and G allele were associated with an increased risk of CAD and IS (CAD: P = 0.005 for GG vs. TT, P = 0.004 for GT/GG v

SUBMITTER: Miao L 

PROVIDER: S-EPMC5629769 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature