Association between habenula dysfunction and motivational symptoms in unmedicated major depressive disorder.

ABSTRACT: The lateral habenula plays a central role in reward and punishment processing and has been suggested to drive the cardinal symptom of anhedonia in depression. This hypothesis is largely based on observations of habenula hypermetabolism in animal models of depression, but the activity of habenula and its relationship with clinical symptoms in patients with depression remains unclear. High-resolution functional magnetic resonance imaging (fMRI) and computational modelling were used to investigate the activity of the habenula during a probabilistic reinforcement learning task with rewarding and punishing outcomes in 21 unmedicated patients with major depression and 17 healthy participants. High-resolution anatomical scans were also acquired to assess group differences in habenula volume. Heal

SUBMITTER: Liu WH 

PROVIDER: S-EPMC5629818 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature