Cross-phenotype association mapping of the MHC identifies genetic variants that differentiate psoriatic arthritis from psoriasis.

ABSTRACT:

Objectives

Psoriatic arthritis (PsA) is a chronic inflammatory arthritis, with a strong heritable component, affecting patients with psoriasis. Here we attempt to identify genetic variants within the major histocompatibility complex (MHC) that differentiate patients with PsA from patients with cutaneous psoriasis alone (PsC).

Methods

2808 patients with PsC, 1945 patients with PsA and 8920 population controls were genotyped. We imputed SNPs, amino acids and classical HLA alleles across the MHC and tested for association with PsA compared to population controls and the PsC patient group. In addition we investigated the impact of the age of disease onset on associations.

Results

HLA-C*06:02 was protective of PsA compared to PsC (p=9.57×10^-66, OR 0.37). The HLA

SUBMITTER: Bowes J 

PROVIDER: S-EPMC5629941 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature