Ferumoxytol-enhanced magnetic resonance imaging assessing inflammation after myocardial infarction.

ABSTRACT:

Objectives

Macrophages play a central role in the cellular inflammatory response to myocardial infarction (MI) and predict subsequent clinical outcomes. We aimed to assess temporal changes in cellular inflammation and tissue oedema in patients with acute MI using ultrasmallsuperparamagnetic particles of iron oxide (USPIO)-enhanced MRI.

Methods

Thirty-one patients were recruited following acute MI and followed up for 3 months with repeated T2 and USPIO-enhanced T2*-mapping MRI. Regions of interest were categorised into infarct, peri-infarct and remote myocardial zones, and compared with control tissues.

Results

Following a single dose, USPIO enhancement was detected in the myocardium until 24 hours (p<0.0001). Histology confirmed colocalisation of iron and macrophages

SUBMITTER: Stirrat CG 

PROVIDER: S-EPMC5629948 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature