Neuronal inhibition of the autophagy nucleation complex extends life span in post-reproductive C. elegans.

ABSTRACT: Autophagy is a ubiquitous catabolic process that causes cellular bulk degradation of cytoplasmic components and is generally associated with positive effects on health and longevity. Inactivation of autophagy has been linked with detrimental effects on cells and organisms. The antagonistic pleiotropy theory postulates that some fitness-promoting genes during youth are harmful during aging. On this basis, we examined genes mediating post-reproductive longevity using an RNAi screen. From this screen, we identified 30 novel regulators of post-reproductive longevity, including pha-4 Through downstream analysis of pha-4, we identified that the inactivation of genes governing the early stages of autophagy up until the stage of vesicle nucleation, such as bec-1, strongly exte

SUBMITTER: Wilhelm T 

PROVIDER: S-EPMC5630021 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature