Identification of a core TP53 transcriptional program with highly distributed tumor suppressive activity.

ABSTRACT: The tumor suppressor TP53 is the most frequently mutated gene product in human cancer. Close to half of all solid tumors carry inactivating mutations in the TP53 gene, while in the remaining cases, TP53 activity is abrogated by other oncogenic events, such as hyperactivation of its endogenous repressors MDM2 or MDM4. Despite identification of hundreds of genes regulated by this transcription factor, it remains unclear which direct target genes and downstream pathways are essential for the tumor suppressive function of TP53. We set out to address this problem by generating multiple genomic data sets for three different cancer cell lines, allowing the identification of distinct sets of TP53-regulated genes, from early transcriptional targets through to late targets controlled at the t

SUBMITTER: Andrysik Z 

PROVIDER: S-EPMC5630028 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature