Redundant and incoherent regulations of multiple phenotypes suggest microRNAs' role in stability control.

ABSTRACT: Each microRNA (miRNA) represses a web of target genes and, through them, controls multiple phenotypes. The difficulties inherent in such controls cast doubt on how effective miRNAs are in driving phenotypic changes. A "simple regulation" model posits "one target-one phenotype" control under which most targeting is nonfunctional. In an alternative "coordinate regulation" model, multiple targets are assumed to control the same phenotypes coherently, and most targeting is functional. Both models have some empirical support but pose different conceptual challenges. Here, we concurrently analyze multiple targets and phenotypes associated with the miRNA-310 family (miR310s) of Drosophila Phenotypic rescue in the mir310s knockout background is achieved by promoter-directed RNA inter

SUBMITTER: Liufu Z 

PROVIDER: S-EPMC5630030 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature