Sequence features of viral and human Internal Ribosome Entry Sites predictive of their activity.

ABSTRACT: Translation of mRNAs through Internal Ribosome Entry Sites (IRESs) has emerged as a prominent mechanism of cellular and viral initiation. It supports cap-independent translation of select cellular genes under normal conditions, and in conditions when cap-dependent translation is inhibited. IRES structure and sequence are believed to be involved in this process. However due to the small number of IRESs known, there have been no systematic investigations of the determinants of IRES activity. With the recent discovery of thousands of novel IRESs in human and viruses, the next challenge is to decipher the sequence determinants of IRES activity. We present the first in-depth computational analysis of a large body of IRESs, exploring RNA sequence features predictive of IRES activity. We identifi

SUBMITTER: Gritsenko AA 

PROVIDER: S-EPMC5630158 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature