Metabotropic Glutamate Receptor 5 and Glutamate Involvement in Major Depressive Disorder: A Multimodal Imaging Study.

ABSTRACT:

Background

Preclinical and postmortem studies have implicated the metabotropic glutamate receptor 5 (mGluR5) in the pathophysiology of major depressive disorder (MDD). The goal of the present study was to determine the role of mGluR5 in a large group of individuals with MDD compared to healthy controls (HC) in vivo with [¹⁸F]FPEB and positron emission tomography (PET). Furthermore, we sought to determine the role glutamate plays on mGluR5 availability in MDD.

Methods

Sixty-five participants (30 MDD and 35 HC) completed [¹⁸F]FPEB PET to estimate the primary outcome measure - mGluR5 volume of distribution (V_T), and the secondary outcome measure - mGluR5 distribution volume ratio (DVR). A subgroup of 39 participants (16 MDD

SUBMITTER: Abdallah CG 

PROVIDER: S-EPMC5630181 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature