Pro-inflammatory fatty acid profile and colorectal cancer risk: A Mendelian randomisation analysis.

ABSTRACT:

Background

While dietary fat has been established as a risk factor for colorectal cancer (CRC), associations between fatty acids (FAs) and CRC have been inconsistent. Using Mendelian randomisation (MR), we sought to evaluate associations between polyunsaturated (PUFA), monounsaturated (MUFA) and saturated FAs (SFAs) and CRC risk.

Methods

We analysed genotype data on 9254 CRC cases and 18,386 controls of European ancestry. Externally weighted polygenic risk scores were generated and used to evaluate associations with CRC per one standard deviation increase in genetically defined plasma FA levels.

Results

Risk reduction was observed for oleic and palmitoleic MUFAs (OR_OA = 0.77, 95% CI: 0.65-0.92, P = 3.9 × 10^-3; OR_POA = 0.36, 95% CI: 0.1

SUBMITTER: May-Wilson S 

PROVIDER: S-EPMC5630201 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature