Unexpected high robustness of electrochemical cross-coupling for a broad range of current density.

ABSTRACT: Electro-organic synthesis is a powerful technique for the sustainable preparation of compounds. However, many electrosynthetic reactions require complex equipment, are limited to a very narrow current density range, or have very long reaction times; some also involve nonselective transformations and bad scalability. The robust and selective synthesis of nonsymmetric biphenols and partially protected derivatives is established by anodic C-C cross-coupling. The setup is simple, involving constant current conditions and undivided cells. Its key is a unique electrolyte system based on fluorous alcohols and mixtures, particularly 1,1,1,3,3,3-hexafluoroisopropanol. This allows variations of the current density of more than two orders of magnitude without decreasing selectivity or product yield.

SUBMITTER: Wiebe A 

PROVIDER: S-EPMC5630235 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature