Consolidation Promotes the Emergence of Representational Overlap in the Hippocampus and Medial Prefrontal Cortex.

ABSTRACT: Structured knowledge is thought to form, in part, through the extraction and representation of regularities across overlapping experiences. However, little is known about how consolidation processes may transform novel episodic memories to reflect such regularities. In a multi-day fMRI study, participants encoded trial-unique associations that shared features with other trials. Multi-variate pattern analyses were used to measure neural similarity across overlapping and non-overlapping memories during immediate and 1-week retrieval of these associations. We found that neural patterns in the hippocampus and medial prefrontal cortex represented the featural overlap across memories, but only after a week. Furthermore, after a week, the strength of a memory's unique episodic reinstatement durin

SUBMITTER: Tompary A 

PROVIDER: S-EPMC5630271 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature