MicroRNA-149* suppresses hepatic inflammatory response through antagonizing STAT3 signaling pathway.

ABSTRACT: Chronic inflammation is increasingly recognized as an important component of tumorigenesis and metabolic diseases. The roles of microRNA149* (miRNA149*) in inflammation remain poorly understood. Here, we demonstrate that miR-149* is a suppressor of STAT3-mediated inflammation. MiR-149*^-/- mice were generated with CRISPR/CAS9 technique. In a lipopolysaccharide (LPS)-induced inflammation model, miR-149*^-/- mice show more severe liver injury and inflammation, compared with wild-type (WT) mice. MiR-149*^-/- mice also displayed elevated messenger RNA (mRNA) levels of interleukin (IL)-6, inducible nitric oxide synthase (iNOS), complement C3 (C3) and IL-4 in response to LPS. Then miR-149* agomir administration is largely able to alleviate the LPS-induced some infla

SUBMITTER: Zhang Q 

PROVIDER: S-EPMC5630339 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature