A potential prognostic biomarker SPC24 promotes tumorigenesis and metastasis in lung cancer.

ABSTRACT:

Results

SPC24 is over-expressed in clinical lung adenocarcinoma samples, and high level of SPC24 is associated with advanced stages of lung tumors. Knocking down SPC24 repressed cell growth and promoted apoptosis. SPC24 deficiency reduced cancer cell migration as well. E-cadherin, one of the epithelial-mesenchymal transition markers, was up-regulated in the knockdown cells, along with down-regulation of N-cadherin and Vimentin. Oncomine expression analyses further confirmed that high level of SPC24 is associated with tumors from smokers, recurrent patients, or patients with shorter survivals.

Purpose and methods

To reveal the role of SPC24, an important component of kinetochore, in the tumorigenesis of lung cancer, we performed Oncomine and immunohistochemistry (IHC)

SUBMITTER: Zhou J 

PROVIDER: S-EPMC5630346 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature