NHERF1 together with PARP1 and BRCA1 expression as a new potential biomarker to stratify breast cancer patients.

ABSTRACT: It has been recognized that Na⁺/H⁺ Exchanger Regulatory Factor 1 (NHERF1) in breast cancer (BC) acts as a tumor suppressor or as an oncogenic protein, depending on its subcellular localization. This study aims to correlate NHERF1 expression to BRCA1 and PARP1 proteins, to investigate their relationship, and their biological and clinical significance. Using immunohistochemistry on tissue microarrays, we evaluated subcellular NHERF1, BRCA1 and PARP1 expression in 308 BCs including a subgroup (n=80) of triple negative BCs (TNBCs). Herein, we show that nuclear NHERF1 (nNHERF1) expression was significantly associated with nuclear BRCA1 (nBRCA1) expression (p=0.0008), and an association was also found between nuclear PARP1 (nPARP1) and nBRCA1 (p<0.0001). Cytop

SUBMITTER: Mangia A 

PROVIDER: S-EPMC5630367 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature