Similar response profile to neoadjuvant chemotherapy, but different survival, in inflammatory versus locally advanced breast cancers.

ABSTRACT: Inflammatory breast cancer (IBC) is a very aggressive form of breast cancer, as compared to locally advanced breast cancer (LABC). Neoadjuvant chemotherapy followed by surgery is the standard treatment in both cases. Whether IBC is less chemosensitive than LABC remains unclear. We retrospectively compared the rate of pathological complete response (pCR) to neoadjuvant chemotherapy in IBC and LABC.

Methods

Patients with IBC or LABC treated with neoadjuvant anthracycline-based chemotherapy followed by surgery were selected from our institutional database. The primary endpoint was the pCR rate, defined as absence of invasive tumor in breast and axillary lymph nodes.

Results

A total of 450 patients were included, 144 with IBC and 306 with LABC. The pCR rate was similar between th

SUBMITTER: Monneur A 

PROVIDER: S-EPMC5630389 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature