Neonatal abstinence syndrome and early childhood morbidity and mortality in Washington state: a retrospective cohort study.

ABSTRACT:

Objective

The objective of the study was to evaluate the association between neonatal abstinence syndrome (NAS) and long-term childhood morbidity and infant mortality.

Study design

We conducted a cohort study of infants born in Washington State during 1990 to 2008 who were diagnosed with NAS (n=1900) or were unexposed (n=12,283, frequency matched by birth year). 5-year hospital readmissions and infant mortality were ascertained.

Results

Children with history of NAS had increased risk of readmission during the first 5 years of life relative to unexposed children; this remained statistically significant after adjustment for maternal age, maternal education, gestational age and intrapartum smoking status (readmission rates: NAS=21.3%, unexposed=12.7%, adjusted relative r

SUBMITTER: Witt CE 

PROVIDER: S-EPMC5630496 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature