The effect of adjunctive telmisartan treatment on psychopathology and cognition in patients with schizophrenia.

ABSTRACT:

Objective

This study examined the effect of adjunctive telmisartan on psychopathology and cognition in olanzapine- or clozapine-treated patients with schizophrenia.

Method

In a 12-week randomized, double-blind, placebo-controlled study, patients diagnosed with schizophrenia or schizoaffective disorder received either telmisartan (80 mg once per day) or placebo. Psychopathology was assessed using the Positive and Negative Syndrome Scale (PANSS) and the Scale for Assessment of Negative Symptoms (SANS), and a neuropsychological battery was used to assess cognitive performance. Assessments for psychopathology and cognition were conducted at baseline and week 12.

Results

Fifty-four subjects were randomized, and 43 completed the study (22 in the telmisartan group, 21 in the

SUBMITTER: Fan X 

PROVIDER: S-EPMC5630515 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature