Identification and validation of uterine stimulant methylergometrine as a potential inhibitor of caspase-1 activation.

ABSTRACT: Inflammasomes are intracellular multiprotein complexes of the innate immune system. Upon an inflammatory insult, such as infection or intracellular damage, a nucleotide-binding oligomerization domain-like receptor (NLR) sensor protein and the adaptor protein ASC (apoptosis-associated speck-like protein containing a caspase activation and recruitment domain) are assembled to activate protease procaspase-1. This protease processes pro-IL-1β and pro-IL-18 cytokines, which are released to induce the inflammatory response. De-regulation of inflammasome contributes to the progression of several diseases, such as Alzheimer's disease, diabetes, cancer, inflammatory and autoimmune disorders. We herein describe the identification of methylergometrine (MEM), a drug currently used as a smooth muscle c

SUBMITTER: Garcia-Lainez G 

PROVIDER: S-EPMC5630661 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature