The Peyer's Patch Mononuclear Phagocyte System at Steady State and during Infection.

ABSTRACT: The gut represents a potential entry site for a wide range of pathogens including protozoa, bacteria, viruses, or fungi. Consequently, it is protected by one of the largest and most diversified population of immune cells of the body. Its surveillance requires the constant sampling of its encounters by dedicated sentinels composed of follicles and their associated epithelium located in specialized area. In the small intestine, Peyer's patches (PPs) are the most important of these mucosal immune response inductive sites. Through several mechanisms including transcytosis by specialized epithelial cells called M-cells, access to the gut lumen is facilitated in PPs. Although antigen sampling is critical to the initiation of the mucosal immune response, pathogens have evolved strategies to take

SUBMITTER: Da Silva C 

PROVIDER: S-EPMC5630697 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature