Ancient Eukaryotic Origin and Evolutionary Plasticity of Nuclear Lamina.

ABSTRACT: The emergence of the nucleus was a major event of eukaryogenesis. How the nuclear envelope (NE) arose and acquired functions governing chromatin organization and epigenetic control has direct bearing on origins of developmental/stage-specific expression programs. The configuration of the NE and the associated lamina in the last eukaryotic common ancestor (LECA) is of major significance and can provide insight into activities within the LECA nucleus. Subsequent lamina evolution, alterations, and adaptations inform on the variation and selection of distinct mechanisms that subtend gene expression in distinct taxa. Understanding lamina evolution has been difficult due to the diversity and limited taxonomic distributions of the three currently known highly distinct nuclear lamina. We rigorousl

SUBMITTER: Koreny L 

PROVIDER: S-EPMC5630835 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature