Modular Approach to pseudo-Neoclerodanes as Designer κ-Opioid Ligands.

ABSTRACT: Informed by previous semisynthetic work on salvinorin A, a modular total synthesis has been developed capable of producing novel compounds targeting the κ-opioid receptor. The strategy has permitted the deliberate simplification and introduction of functionality about the target molecule to provide access to molecular features on salvinorin A otherwise unattainable by semisynthesis. Using this approach, a potent pseudo-neoclerodane κ-opioid receptor ligand (2) has been realized.

SUBMITTER: Sherwood AM 

PROVIDER: S-EPMC5632227 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature