Antiretroviral Drug Resistance Mutations among HIV Treatment Failure Patients in Tehran, Iran.

ABSTRACT:

Background

This study aimed to determine drug resistance mutations in patients with virological failure and find correlation between HIV drug resistance test and viral load.

Methods

Blood sample was collected from 51 patients who suspicious treatment failure in the center of Imam Khomeini Hospital, Tehran, Iran in 2015. Viral voluntary counseling and testing load test was done and the patients with viral load above 1000 copies choose for detection of drug resistance mutations by genotyping method (29 patients).

Results

The majority of patients (82.75) harbored the HIV subtype CRF 35 A-D. The 86.2% patients compromised at least one resistance mutation. The analysis of reverse transcriptase showed M184V (68.9%), T215YISF (44.8%), K103N (27.6%) and the analysis results o

SUBMITTER: Farrokhi M 

PROVIDER: S-EPMC5632328 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature