MiRNA in Circulating Microvesicles as Biomarkers for Age-Related Cognitive Decline.

ABSTRACT: Community dwelling older individuals from the North Florida region were examined for health status and a comprehensive neuropsychological battery, including the Montreal Cognitive Assessment (MoCA), was performed on each participant. A subpopulation (58 females and 39 males) met the criteria for age (60-89) and no evidence of mild cognitive impairment, with a MoCA score ≥23. Despite the stringent criteria for participation, MoCA scores were negatively correlated within the limited age range. Extracellular microvesicles were isolated from the plasma and samples were found to be positive for the exosome marker CD63, with an enrichment of particles within the size range for exosomes. miRNA was extracted and examined using next generation sequencing with a stringent criterion (average of ≥10 c

SUBMITTER: Rani A 

PROVIDER: S-EPMC5632661 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature