Specific Imaging of Bacterial Infection Using 6″-¹⁸F-Fluoromaltotriose: A Second-Generation PET Tracer Targeting the Maltodextrin Transporter in Bacteria.

ABSTRACT: 6″-¹⁸F-fluoromaltotriose is a PET tracer that can potentially be used to image and localize most bacterial infections, much like ¹⁸F-FDG has been used to image and localize most cancers. However, unlike ¹⁸F-FDG, 6″-¹⁸F-fluoromaltotriose is not taken up by inflammatory lesions and appears to be specific to bacterial infections by targeting the maltodextrin transporter that is expressed in gram-positive and gram-negative strains of bacteria. Methods: 6″-¹⁸F-fluoromaltotriose was synthesized with high radiochemical purity and evaluated in several clinically relevant bacterial strains in cultures and in living mice. Results: 6″-¹⁸F-fluoromaltotriose was taken up in both gram-positive and gram-negative bacterial str

SUBMITTER: Gowrishankar G 

PROVIDER: S-EPMC5632736 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature