IL-1β and IL-23 Promote Extrathymic Commitment of CD27⁺CD122^- γδ T Cells to γδT17 Cells.

ABSTRACT: γδT17 cells are a subset of γδ T cells committed to IL-17 production and are characterized by the expression of IL-23R and CCR6 and lack of CD27 expression. γδT17 cells are believed to arise within a narrow time window during prenatal thymic development. In agreement with this concept, we show in this study that adult Rag1^-/- recipient mice of Il23r^gfp/+ (IL-23R reporter) bone marrow selectively lack IL-23R⁺ γδT17 cells. Despite their absence in secondary lymphoid tissues during homeostasis, γδT17 cells emerge in bone marrow chimeric mice upon induction of skin inflammation by topical treatment with imiquimod cream (Aldara). We demonstrate that IL-1β and IL-23 together are able to promote the development of bona fide γδT17 cells from periphera

SUBMITTER: Muschaweckh A 

PROVIDER: S-EPMC5632841 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature