Diagnostic accuracy of C-reactive protein for active pulmonary tuberculosis: a meta-analysis.

ABSTRACT:

Setting

Systematic screening for active pulmonary tuberculosis (PTB) is recommended for high-risk populations, including people living with the human immunodeficiency virus (PLHIV); however, currently recommended TB screening tools are inadequate for most high-burden settings.

Objective

To determine whether C-reactive protein (CRP) possesses the necessary test characteristics to screen individuals for active PTB.

Design

We performed a systematic review and meta-analysis of studies evaluating the diagnostic accuracy of CRP (10 mg/l cut-off point) for culture-positive PTB. Pooled diagnostic accuracy estimates were generated using random-effects meta-analysis for out-patients and in-patients, and for pre-specified subgroups based on HIV status and test indication.

Res

SUBMITTER: Yoon C 

PROVIDER: S-EPMC5633000 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature