Virologic outcomes in early antiretroviral treatment: HPTN 052.

ABSTRACT:

Introduction

The HIV Prevention Trials Network (HPTN) 052 trial demonstrated that early antiretroviral therapy (ART) prevented 93% of HIV transmission events in serodiscordant couples. Some linked infections were observed shortly after ART initiation or after virologic failure.

Objective

To evaluate factors associated with time to viral suppression and virologic failure in participants who initiated ART in HPTN 052.

Methods

1566 participants who had a viral load (VL) > 400 copies/mL at enrollment were included in the analyses. This included 832 in the early ART arm (CD4 350-550 cells/mm³ at ART initiation) and 734 in the delayed ART arm (204 with a CD4 < 250 cells/mm³ at ART initiation; 530 with any CD4 at ART initiation). Viral suppression was d

SUBMITTER: Eshleman SH 

PROVIDER: S-EPMC5633001 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature