The ATAD2 bromodomain binds different acetylation marks on the histone H4 in similar fuzzy complexes.

ABSTRACT: Bromodomains are protein modules adopting conserved helix bundle folds. Some bromodomain-containing proteins, such as ATPase family AAA domain-containing protein 2 (ATAD2), isoform A, have attracted much interest because they are overexpressed in many types of cancer. Bromodomains bind to acetylated lysine residues on histone tails and thereby facilitate the reading of the histone code. Epigenetic regulators in general have been implicated as indicators, mediators, or causes of a large number of diseases and disorders. To interfere with or modulate these processes, it is therefore of fundamental interest to understand the molecular mechanisms by which epigenetic regulation occurs. Here, we present results from molecular dynamics simulations of a doubly acetylated histone H4 peptide bound t

SUBMITTER: Langini C 

PROVIDER: S-EPMC5633134 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature