Modulation of the gut microbiota by the mixture of fish oil and krill oil in high-fat diet-induced obesity mice.

ABSTRACT: Previous studies confirmed that dietary supplements of fish oil and krill oil can alleviate obesity in mice, but the underlying mechanism remains unclear. This study aims to discern whether oil treatment change the structure of the gut microbiota during the obesity alleviation. The ICR mice received high-fat diet (HFD) continuously for 12 weeks after two weeks of acclimatization with a standard chow diet, and the mice fed with a standard chow diet were used as the control. In the groups that received HFD with oil supplementation, the weight gains were attenuated and the liver index, total cholesterol, triglyceride and low-density lipoprotein cholesterol were reduced stepwise compared with the HFD group, and the overall structure of the gut microbiota, which was modulated in the HFD group,

SUBMITTER: Cui C 

PROVIDER: S-EPMC5633193 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature