Persistent organic pollutants in infants and toddlers: Relationship between concentrations in matched plasma and faecal samples.

ABSTRACT: Early-childhood biomonitoring of persistent organic pollutants (POPs) is challenging due to the logistic and ethical limitations associated with blood sampling. We investigated using faeces as a non-invasive matrix to estimate internal exposure to POPs. The concentrations of selected POPs were measured in matched plasma and faecal samples collected from 20 infants/toddlers (aged 13±4.8months), including a repeat sample time point for 13 infants (~5months apart). We observed higher rates of POP quantification in faeces (2g dry weight) than in plasma (0.5mL). Among the five chemicals that had quantification frequencies over 50% in both matrices, except for HCB, log concentration in faeces (C_f) and blood (C_b) were correlated (r>0.74, P<0.05) for p.p'-dichlorodiphenyldich

SUBMITTER: Chen Y 

PROVIDER: S-EPMC5633368 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature