Partial pressure of arterial carbon dioxide and survival to hospital discharge among patients requiring acute mechanical ventilation: A cohort study.

ABSTRACT:

Purpose

To describe the prevalence of hypocapnia and hypercapnia during the earliest period of mechanical ventilation, and determine the association between P_aCO₂ and mortality.

Materials and methods

A cohort study using an emergency department registry of mechanically ventilated patients. P_aCO₂ was categorized: hypocapnia (<35mmHg), normocapnia (35-45mmHg), and hypercapnia (>45mmHg). The primary outcome was survival to hospital discharge.

Results

A total of 1,491 patients were included. Hypocapnia occurred in 375 (25%) patients and hypercapnia in 569 (38%). Hypercapnia (85%) had higher survival rate compared to normocapnia (74%) and hypocapnia (66%), P<0.001. P_aCO₂ was an independent predictor of survi

SUBMITTER: Fuller BM 

PROVIDER: S-EPMC5633513 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature