Risk factors for early mortality on antiretroviral therapy in advanced HIV-infected adults.

ABSTRACT:

Background

Many HIV-infected individuals present with advanced HIV disease. These patients are at high risk of death after antiretroviral therapy (ART) initiation, but risk factors for death in these patients are unclear.

Methods

We used data from a multisite randomized trial comparing empiric vs. preventive tuberculosis therapy in HIV-infected adults initiating ART with CD4 T-cell counts less than 50 cells/μl to evaluate risk factors for death within 48 weeks after ART initiation. Cox proportional hazards models were fit to evaluate characteristics present at baseline and at 4 weeks after ART initiation, including the week 4 CD4 T-cell response and new opportunistic infections.

Results

Of 850 enrolled, the median pre-ART CD4 T-cell count was 18 cells/μl and 67 (7.9%)

SUBMITTER: Bisson GP 

PROVIDER: S-EPMC5633516 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature