Evaluation of a prediction model for colorectal cancer: retrospective analysis of 2.5 million patient records.

ABSTRACT: Earlier detection of colorectal cancer greatly improves prognosis, largely through surgical excision of neoplastic polyps. These include benign adenomas which can transform over time to malignant adenocarcinomas. This progression may be associated with changes in full blood count indices. An existing risk algorithm derived in Israel stratifies individuals according to colorectal cancer risk using full blood count data, but has not been validated in the UK. We undertook a retrospective analysis using the Clinical Practice Research Datalink. Patients aged over 40 with full blood count data were risk-stratified and followed up for a diagnosis of colorectal cancer over a range of time intervals. The primary outcome was the area under the receiver operating characteristic curve for the 18-24-mo

SUBMITTER: Birks J 

PROVIDER: S-EPMC5633543 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature