The -29G/A FSH receptor gene polymorphism is associated with higher FSH and LH levels in normozoospermic men.

ABSTRACT:

Purpose

The functional role of the FSHR promoter -29G/A polymorphism (rs1394205) in men is not clear. Some studies failed to find a relationship between the FSHR -29G/A and follicle-stimulating hormone (FSH) levels and did not associate the SNP with male infertility. Only one study showed that the FSHR -29 SNP modulates serum FSH levels in Baltic young male cohort. Because the SNP -29G/A has to be shown to have a strong effect on in vitro transcription activity of the FSHR promoter and the activation of FSHR is necessary for a normal FSH function, this study was undertaken to assess whether the FSHR -29G/A SNP modulates the gonadal endocrine function in men.

Methods

A total of 200 men with alteration of conventional sperm parameters or normozoospermia (according to the param

SUBMITTER: Tamburino L 

PROVIDER: S-EPMC5633567 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature