Performance and economic evaluation of the molecular detection of pathogens for patients with severe infections: the EVAMICA open-label, cluster-randomised, interventional crossover trial.

ABSTRACT:

Purpose

Microbiological diagnosis (MD) of infections remains insufficient. The resulting empirical antimicrobial therapy leads to multidrug resistance and inappropriate treatments. We therefore evaluated the cost-effectiveness of direct molecular detection of pathogens in blood for patients with severe sepsis (SES), febrile neutropenia (FN) and suspected infective endocarditis (SIE).

Methods

Patients were enrolled in a multicentre, open-label, cluster-randomised crossover trial conducted during two consecutive periods, randomly assigned as control period (CP; standard diagnostic workup) or intervention period (IP; additional testing with LightCycler^®SeptiFast). Multilevel models used to account for clustering were stratified by clinical setting (SES, FN, SIE).

SUBMITTER: Cambau E 

PROVIDER: S-EPMC5633620 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature