Effects of Oleo Gum Resin of Ferula assa-foetida L. on Senescence in Human Dermal Fibroblasts: - Asafoetida reverses senescence in fibroblasts.

ABSTRACT:

Objectives

Based on data from Chinese and Indian traditional herbal medicines, gum resin of Ferula assa-foetida (sometimes referred to asafetida or asafoetida) has several therapeutic applications. The authors of various studies have claimed that asafetida has cytotoxic, antiulcer, anti-neoplasm, anti-cancer, and anti-oxidative effects. In present study, the anti-aging effect of asafetida on senescent human dermal fibroblasts was evaluated.

Methods

Senescence was induced in in vitro cultured human dermal fibroblasts (HDFs) through exposure to H₂O₂, and the incidence of senescence was recognized by using cytochemical staining for the activity of β-galactosidase. Then, treatment with oleo gum resin of asafetida was started to evaluate

SUBMITTER: Moghadam FH 

PROVIDER: S-EPMC5633674 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature