ACCORDION MIND: results of the observational extension of the ACCORD MIND randomised trial.

ABSTRACT:

Aims/hypothesis

The Memory in Diabetes (MIND) substudy of the Action to Control Cardiovascular Risk in Diabetes (ACCORD) study, a double 2x2 factorial parallel-group randomised clinical trial, tested whether intensive compared with standard management of hyperglycaemia, BP or lipid levels reduced cognitive decline and brain atrophy in 2977 people with type 2 diabetes. We describe the results of the observational extension study, ACCORDION MIND (ClinicalTrials.gov registration no. NCT00182910), which aimed to measure the long-term effects of the three ACCORD interventions on cognitive and brain structure outcomes approximately 4 years after the trial ended.

Methods

Participants (mean diabetes duration 10 years; mean age 62 years at baseline) received a fourth cognitive assess

SUBMITTER: Murray AM 

PROVIDER: S-EPMC5633725 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature