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Predicting Risk of Infection in Patients with Newly Diagnosed Multiple Myeloma: Utility of Immune Profiling.

ABSTRACT: A translational study in patients with myeloma to determine the utility of immune profiling to predict infection risk in patients with hematological malignancy was conducted.Baseline, end of induction, and maintenance peripheral blood mononuclear cells from 40 patients were evaluated. Immune cell populations and cytokines released from 1?×?106?cells/ml cultured in the presence of a panel of stimuli (cytomegalovirus, influenza, S. pneumoniae, phorbol myristate acetate/ionomycin) and in media alone were quantified. Patient characteristics and infective episodes were captured from clinical records. Immunological variables associated with increased risk for infection in the 3-month period following sample collection were identified using univariate analysis (p?

SUBMITTER: Teh BW 

PROVIDER: S-EPMC5633726 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

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Predicting Risk of Infection in Patients with Newly Diagnosed Multiple Myeloma: Utility of Immune Profiling.

Teh Benjamin W BW   Harrison Simon J SJ   Allison Cody Charles CC   Slavin Monica A MA   Spelman Tim T   Worth Leon J LJ   Thursky Karin A KA   Ritchie David D   Pellegrini Marc M  

Frontiers in immunology 20171005

<h4>Background</h4>A translational study in patients with myeloma to determine the utility of immune profiling to predict infection risk in patients with hematological malignancy was conducted.<h4>Methods</h4>Baseline, end of induction, and maintenance peripheral blood mononuclear cells from 40 patients were evaluated. Immune cell populations and cytokines released from 1 × 10<sup>6</sup> cells/ml cultured in the presence of a panel of stimuli (cytomegalovirus, influenza, <i>S. pneumoniae</i>, p  ...[more]

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