Identification of a RAC/AKT-like gene in Leishmania parasites as a putative therapeutic target in leishmaniasis.

ABSTRACT:

Background

Leishmaniasis is one of the world's most neglected diseases caused by at least 20 different species of the protozoan parasite Leishmania. Although new drugs have become recently available, current therapy for leishmaniasis is still unsatisfactory. A subgroup of serine/threonine protein kinases named as related to A and C protein kinases (RAC), or protein kinase B (PKB)/AKT, has been identified in several organisms including Trypanosoma cruzi parasites. PKB/AKT plays a critical role in mammalian cell signaling promoting cell survival and is a major drug target in cancer therapy. However, the role of protozoan parasitic PKB/AKT remains to be elucidated.

Results

We have found that anti-human AKT antibodies recognized a protein of about 57 kDa in Leishmania spp. paras

SUBMITTER: Varela-M RE 

PROVIDER: S-EPMC5633885 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature